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    <title><string language="fre"><![CDATA[Life of a sample]]></string></title>
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    <description>
        <string language="fre"><![CDATA[Clinical
and biological samples : opportunities and challenges for translational
research

 
The first purpose of this talk is to provide ton
non clinical researchers some main technical, ethical and reglementary issues
for their access to biological samples and especially tumoral tissues which are
stored  in pathology departments or tumor
banks.  The second one is to explain to
scientists that their project will not be successful if the sample collection
is not associated with relevant clinical and biopathological annotations

Finally, financial and ethical problems will be
discussed as cancer biobanks funding becomes problematic and there is also an
urgent need to refine their policy considering the most frequent tumor subtypes
which may be available in several biobanks with redundancy and the access of
researchers to routine diagnostic samples or rare tumor subtypes which are not
primarily stored for research but that can be qualified for research by an
Ethical Committee.

Samples collected in daily practice are of
diverse origins and subtypes:  fresh
tissues, cell suspension, fixed biopsies, surgical specimens. All of them may
be altered by adverse preanalytical factors such as cold ischemia, delayed
fixation or freezing times which are not always known parameters. Therefore,
research collection can be set up with knowledge of these parameters and
alternative procedures such as RNA later prior to freezing. Accreditation of
pathology department will also make possible to limit preanalytical artefacts
which are critical according to the tissue subtype and technique used for
analysis with robust and more sensitive ones. 

The research collection needs to be associated
with basic clinical and pathological parameters but all of them are only
available when a clinical database with evolutive features is designed and
maintained. Despite the efforts of these clinical databases, the life of the
sample needs to be managed independently at the biopathology level. In fact
there are two different situations:  one
is when the cancer biobank and the biopathology department directly involved in
the research project. Another seen at the Bordeaux University Hospital is when
more than 10 research collection are setup in the context of regional, national
or international project with centralized management and funding of the
clinical database as well as of the scientific advisory board for access to the
samples.  Despite the presence of such
clinical database, the scientific project cannot be conducted without a
specific reanalysis of biopathological data owing to the diversity of tumour
histological and genetic subtypes, especially when changes in the
classification of the tumor subtypes (lung, liver, lymphoma for example) have
occurred. Both clinicians and scientists are not aware that their project will
not only need funding for access to tissue but that they will need to involve
an expert biopathologist in their project.

Whatever the tumor bank subtype, the process
for storing, management and sample access are regulated through certified
procedure NFS 96900 in France. Finally, the access to sample is restricted by
ethical and regulatory procedures for which the tumor bank is not in charge but
has together with the researcher to cope with.


Cette présentation a été donnée dans le cadre du BRIO SIRIC
scientific day 3 organisé annuellement par le SIRIC BRIO et qui a pour but de
réunir tous les acteurs du SIRIC BRIO et plus largement de la cancérologie à
Bordeaux.]]></string></description>
    <keyword><string language="fre"><![CDATA[cancer]]></string></keyword><keyword><string language="fre"><![CDATA[Oncologie]]></string></keyword><keyword><string language="fre"><![CDATA[Thérapie]]></string></keyword><keyword><string language="fre"><![CDATA[Recherche]]></string></keyword>
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REV:2015-12-13 00:01:35
FN:Jean-Philippe MERLIO
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            <date><dateTime>2015-11-10</dateTime></date>
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